This page contains the normal tissue dose constraints from the HyTEC publications, with organ names labeled according to the AAPM TG 263 naming convention.
A few notes on the structure names:
Organ | Constraint | Notes |
Brain | V12Gy < 5 cc | Symptomatic necrosis (10%) |
Brain | V12Gy < 10 cc | Symptomatic necrosis (15%) |
Brain | V12Gy < 15 cc | Symptomatic necrosis (20%) |
Optic Chaism | Max < 10 Gy | Neuropathy (1%). Lower limit |
Optic Chaism | Max < 12 Gy | Neuropathy (1%). Upper limit |
Optic Nerve Left | Max < 10 Gy | Neuropathy (1%). Lower limit |
Optic Nerve Left | Max < 12 Gy | Neuropathy (1%). Upper limit |
Optic Nerve Right | Max < 10 Gy | Neuropathy (1%). Lower limit |
Optic Nerve Right | Max < 12 Gy | Neuropathy (1%). Upper limit |
Spinal Cord | Max < 12.4 Gy | Myelopathy (1-5%). No prior RT. Lower limit |
Spinal Cord | Max < 14 Gy | Myelopathy (1-5%). No prior RT. Upper limit |
Organ | Constraint | Notes |
Brain | V20Gy < 20 cc | Edema or necrosis (10%) |
Brain | V20Gy < 30 cc | Edema or necrosis (20%) |
Optic Chaism | Max < 20 Gy | Neuropathy (1%) |
Optic Nerve Left | Max < 20 Gy | Neuropathy (1%) |
Optic Nerve Right | Max < 20 Gy | Neuropathy (1%) |
Liver | Mean < 13 Gy | Grade 3+ liver enzyme change (< 20%). Liver primary. Excludes GTV |
Liver | Mean < 15 Gy | Grade 3+ liver enzyme change (< 20%). Liver mets. Excludes GTV |
Liver | D700cc < 15 Gy | Liver dysfunction and grade 3-5 GI toxicity (< 13%). Excludes GTV. Lower limit |
Liver | D700cc < 17 Gy | Liver dysfunction and grade 3-5 GI toxicity (< 13%). Excludes GTV. Upper limit |
Lungs | Mean < 8 Gy | Grade 2+ toxicity (10-15%). Excludes target |
Lungs | V20Gy < 10 % | Grade 2+ toxicity (10-15%). Excludes target. Lower limit |
Lungs | V20Gy < 15 % | Grade 2+ toxicity (10-15%). Excludes target. Upper limit |
Spinal Cord | Max < 20.3 Gy | Myelopathy (1-5%). No prior RT. Lower limit |
Spinal Cord | Max < 23.1 Gy | Myelopathy (1-5%). No prior RT. Upper limit |
Organ | Constraint | Notes |
Bladder | V100% < 5 cc | Late grade 2+ urinary toxicity (< 20%). Prostate SBRT. Lower limit |
Bladder | V100% < 10 cc | Late grade 2+ urinary toxicity (< 20%). Prostate SBRT. Upper limit |
Liver | D700cc < 15 Gy | Liver dysfunction and grade 3-5 GI toxicity (< 13%). Excludes GTV. Lower limit |
Liver | D700cc < 17 Gy | Liver dysfunction and grade 3-5 GI toxicity (< 13%). Excludes GTV. Upper limit |
Lungs | Mean < 8 Gy | Grade 2+ toxicity (10-15%). Excludes target |
Lungs | V20Gy < 10 % | Grade 2+ toxicity (10-15%). Excludes target. Lower limit |
Lungs | V20Gy < 15 % | Grade 2+ toxicity (10-15%). Excludes target. Upper limit |
Rectum | Max < 35 Gy | Late grade 3+ bowel toxicity (< 3%). Prostate SBRT. Lower limit |
Rectum | Max < 38 Gy | Late grade 3+ bowel toxicity (< 3%). Prostate SBRT. Upper limit |
Spinal Cord | Max < 23 Gy | Myelopathy (1-5%). No prior RT. Lower limit |
Spinal Cord | Max < 26.2 Gy | Myelopathy (1-5%). No prior RT. Upper limit |
Urethra | Max < 38 Gy | Late grade 2+ urinary toxicity (< 20%). Prostate SBRT. Lower limit |
Urethra | Max < 42 Gy | Late grade 2+ urinary toxicity (< 20%). Prostate SBRT. Upper limit |
Organ | Constraint | Notes |
Bladder | V100% < 5 cc | Late grade 2+ urinary toxicity (< 20%). Prostate SBRT. Lower limit |
Bladder | V100% < 10 cc | Late grade 2+ urinary toxicity (< 20%). Prostate SBRT. Upper limit |
Brain | V24Gy < 20 cc | Edema or necrosis (10%) |
Brain | V24Gy < 30 cc | Edema or necrosis (20%) |
Carotid Artery Left | Max < 20 Gy | Grade 3-5 bleeding (2-12%). No prior RT. Lower limit |
Carotid Artery Left | Max < 30 Gy | Grade 3-5 bleeding (2-12%). No prior RT. Upper limit |
Carotid Artery Left | D0.5cc < 20 Gy | Grade 3-5 bleeding (2-12%). No prior RT |
Carotid Artery Right | Max < 20 Gy | Grade 3-5 bleeding (2-12%). No prior RT. Lower limit |
Carotid Artery Right | Max < 30 Gy | Grade 3-5 bleeding (2-12%). No prior RT. Upper limit |
Carotid Artery Right | D0.5cc < 20 Gy | Grade 3-5 bleeding (2-12%). No prior RT |
Optic Chaism | Max < 25 Gy | Neuropathy (1%) |
Optic Nerve Left | Max < 25 Gy | Neuropathy (1%) |
Optic Nerve Right | Max < 25 Gy | Neuropathy (1%) |
Liver | D700cc < 15 Gy | Liver dysfunction and grade 3-5 GI toxicity (< 13%). Excludes GTV. Lower limit |
Liver | D700cc < 17 Gy | Liver dysfunction and grade 3-5 GI toxicity (< 13%). Excludes GTV. Upper limit |
Lungs | Mean < 8 Gy | Grade 2+ toxicity (10-15%). Excludes target |
Lungs | V20Gy < 10 % | Grade 2+ toxicity (10-15%). Excludes target. Lower limit |
Lungs | V20Gy < 15 % | Grade 2+ toxicity (10-15%). Excludes target. Upper limit |
Rectum | Max < 35 Gy | Late grade 3+ bowel toxicity (< 3%). Prostate SBRT. Lower limit |
Rectum | Max < 38 Gy | Late grade 3+ bowel toxicity (< 3%). Prostate SBRT. Upper limit |
Spinal Cord | Max < 25.3 Gy | Myelopathy (1-5%). No prior RT. Lower limit |
Spinal Cord | Max < 28.8 Gy | Myelopathy (1-5%). No prior RT. Upper limit |
Urethra | Max < 38 Gy | Late grade 2+ urinary toxicity (< 20%). Prostate SBRT. Lower limit |
Urethra | Max < 42 Gy | Late grade 2+ urinary toxicity (< 20%). Prostate SBRT. Upper limit |