Solutio in silico

HyTEC Dose Constraints

This page contains the normal tissue dose constraints from the HyTEC publications, with organ names labeled according to the AAPM TG 263 naming convention. A few notes on the structure names:

Constraint List

HyTEC Constraints (1 Fraction)



OrganConstraintNotes
BrainV12Gy < 5 ccSymptomatic necrosis (10%)
BrainV12Gy < 10 ccSymptomatic necrosis (15%)
BrainV12Gy < 15 ccSymptomatic necrosis (20%)
Optic ChaismMax < 10 GyNeuropathy (1%). Lower limit
Optic ChaismMax < 12 GyNeuropathy (1%). Upper limit
Optic Nerve LeftMax < 10 GyNeuropathy (1%). Lower limit
Optic Nerve LeftMax < 12 GyNeuropathy (1%). Upper limit
Optic Nerve RightMax < 10 GyNeuropathy (1%). Lower limit
Optic Nerve RightMax < 12 GyNeuropathy (1%). Upper limit
Spinal CordMax < 12.4 GyMyelopathy (1-5%). No prior RT. Lower limit
Spinal CordMax < 14 GyMyelopathy (1-5%). No prior RT. Upper limit

HyTEC Constraints (2 Fractions)



OrganConstraintNotes
Spinal CordMax < 17 GyMyelopathy (1-5%). No prior RT. Lower limit
Spinal CordMax < 19.3 GyMyelopathy (1-5%). No prior RT. Upper limit

HyTEC Constraints (3 Fractions)



OrganConstraintNotes
BrainV20Gy < 20 ccEdema or necrosis (10%)
BrainV20Gy < 30 ccEdema or necrosis (20%)
Optic ChaismMax < 20 GyNeuropathy (1%)
Optic Nerve LeftMax < 20 GyNeuropathy (1%)
Optic Nerve RightMax < 20 GyNeuropathy (1%)
LiverMean < 13 GyGrade 3+ liver enzyme change (< 20%). Liver primary. Excludes GTV
LiverMean < 15 GyGrade 3+ liver enzyme change (< 20%). Liver mets. Excludes GTV
LiverD700cc < 15 GyLiver dysfunction and grade 3-5 GI toxicity (< 13%). Excludes GTV. Lower limit
LiverD700cc < 17 GyLiver dysfunction and grade 3-5 GI toxicity (< 13%). Excludes GTV. Upper limit
LungsMean < 8 GyGrade 2+ toxicity (10-15%). Excludes target
LungsV20Gy < 10 %Grade 2+ toxicity (10-15%). Excludes target. Lower limit
LungsV20Gy < 15 %Grade 2+ toxicity (10-15%). Excludes target. Upper limit
Spinal CordMax < 20.3 GyMyelopathy (1-5%). No prior RT. Lower limit
Spinal CordMax < 23.1 GyMyelopathy (1-5%). No prior RT. Upper limit

HyTEC Constraints (4 Fractions)



OrganConstraintNotes
BladderV100% < 5 ccLate grade 2+ urinary toxicity (< 20%). Prostate SBRT. Lower limit
BladderV100% < 10 ccLate grade 2+ urinary toxicity (< 20%). Prostate SBRT. Upper limit
LiverD700cc < 15 GyLiver dysfunction and grade 3-5 GI toxicity (< 13%). Excludes GTV. Lower limit
LiverD700cc < 17 GyLiver dysfunction and grade 3-5 GI toxicity (< 13%). Excludes GTV. Upper limit
LungsMean < 8 GyGrade 2+ toxicity (10-15%). Excludes target
LungsV20Gy < 10 %Grade 2+ toxicity (10-15%). Excludes target. Lower limit
LungsV20Gy < 15 %Grade 2+ toxicity (10-15%). Excludes target. Upper limit
RectumMax < 35 GyLate grade 3+ bowel toxicity (< 3%). Prostate SBRT. Lower limit
RectumMax < 38 GyLate grade 3+ bowel toxicity (< 3%). Prostate SBRT. Upper limit
Spinal CordMax < 23 GyMyelopathy (1-5%). No prior RT. Lower limit
Spinal CordMax < 26.2 GyMyelopathy (1-5%). No prior RT. Upper limit
UrethraMax < 38 GyLate grade 2+ urinary toxicity (< 20%). Prostate SBRT. Lower limit
UrethraMax < 42 GyLate grade 2+ urinary toxicity (< 20%). Prostate SBRT. Upper limit

HyTEC Constraints (5 Fractions)



OrganConstraintNotes
BladderV100% < 5 ccLate grade 2+ urinary toxicity (< 20%). Prostate SBRT. Lower limit
BladderV100% < 10 ccLate grade 2+ urinary toxicity (< 20%). Prostate SBRT. Upper limit
BrainV24Gy < 20 ccEdema or necrosis (10%)
BrainV24Gy < 30 ccEdema or necrosis (20%)
Carotid Artery LeftMax < 20 GyGrade 3-5 bleeding (2-12%). No prior RT. Lower limit
Carotid Artery LeftMax < 30 GyGrade 3-5 bleeding (2-12%). No prior RT. Upper limit
Carotid Artery LeftD0.5cc < 20 GyGrade 3-5 bleeding (2-12%). No prior RT
Carotid Artery RightMax < 20 GyGrade 3-5 bleeding (2-12%). No prior RT. Lower limit
Carotid Artery RightMax < 30 GyGrade 3-5 bleeding (2-12%). No prior RT. Upper limit
Carotid Artery RightD0.5cc < 20 GyGrade 3-5 bleeding (2-12%). No prior RT
Optic ChaismMax < 25 GyNeuropathy (1%)
Optic Nerve LeftMax < 25 GyNeuropathy (1%)
Optic Nerve RightMax < 25 GyNeuropathy (1%)
LiverD700cc < 15 GyLiver dysfunction and grade 3-5 GI toxicity (< 13%). Excludes GTV. Lower limit
LiverD700cc < 17 GyLiver dysfunction and grade 3-5 GI toxicity (< 13%). Excludes GTV. Upper limit
LungsMean < 8 GyGrade 2+ toxicity (10-15%). Excludes target
LungsV20Gy < 10 %Grade 2+ toxicity (10-15%). Excludes target. Lower limit
LungsV20Gy < 15 %Grade 2+ toxicity (10-15%). Excludes target. Upper limit
RectumMax < 35 GyLate grade 3+ bowel toxicity (< 3%). Prostate SBRT. Lower limit
RectumMax < 38 GyLate grade 3+ bowel toxicity (< 3%). Prostate SBRT. Upper limit
Spinal CordMax < 25.3 GyMyelopathy (1-5%). No prior RT. Lower limit
Spinal CordMax < 28.8 GyMyelopathy (1-5%). No prior RT. Upper limit
UrethraMax < 38 GyLate grade 2+ urinary toxicity (< 20%). Prostate SBRT. Lower limit
UrethraMax < 42 GyLate grade 2+ urinary toxicity (< 20%). Prostate SBRT. Upper limit

HyTEC Constraints (6 Fractions)



OrganConstraintNotes
LiverMean < 18 GyGrade 3+ liver enzyme change (< 20%). Liver primary. Excludes GTV
LiverMean < 20 GyGrade 3+ liver enzyme change (< 20%). Liver mets. Excludes GTV
LiverD700cc < 15 GyLiver dysfunction and grade 3-5 GI toxicity (< 13%). Excludes GTV. Lower limit
LiverD700cc < 17 GyLiver dysfunction and grade 3-5 GI toxicity (< 13%). Excludes GTV. Upper limit